Learn about the basics of CBD
Basics of CBD
How does Clinical CBD Work?
Gynecology and obstetrics
Nausea and Vomiting
Effect of Phytocannabinoids on Nausea and Vomiting
Erin M. Rock, Martin A. Sticht, Linda A. Parker
Among over 60 terpeno-phenols derived from the cannabis plant, delta-9-tetrahydrocannabinol (Δ9-THC) has by far been the most studied for its potential to reduce nausea and vomiting. Indeed, the first approved medical use of Δ9-THC was for nausea and vomiting.
However, the remaining compounds in the plant have received relatively less investigation. This chapter reviews recent research on the potential of the phytocannabinoids, cannabidiol (CBD), cannabidiolic acid (CBDA), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), cannabivarin (CBDV), and cannabigerol (CBG) to reduce nausea and vomiting in animal models.
- CBD and CBDA attenuate nausea and vomiting via indirect agonism of the 5-HT1A receptor.
- CBG acts as a 5-HT1A receptor antagonist, reversing the suppressive effect of CBD on nausea and vomiting.
- THCA potently reduces nausea and vomiting, possibly by a CB1 receptor mechanism of action.
- Finally, CBDV, as well as a high dose of THCV, also attenuate nausea. These phytocannabinoids have therapeutic potential that merits further exploration.
Phytocannabinoids and the Gastrointestinal System
Marnie Duncan, Angelo A. Izzo
The plant Cannabis, which has been traditionally employed for the treatment of gastrointestinal ailments, contains both psychotropic phytocannabinoids, such as Δ9-tetrahydrocannabinol (THC) and nonpsychotropic phytocannabinoids, such as cannabidiol (CBD), cannabigerol (CBG), Δ9-tetrahydrocannabivarin (THCV), and cannabichromene (CBC).
Such phytocannabinoids have been shown to modulate, through different mechanisms, a number of gastrointestinal functions, including gastric acid secretion, intestinal motility, visceral sensation, inflammation, and cell proliferation. This chapter focuses on the pharmacology and the potential therapeutic application of Cannabis-derived cannabinoids (phytocannabinoids) in gastrointestinal diseases, with a special reference to irritable bowel syndrome, inflammatory bowel disease, and colon cancer.
Cancer – breast
Cancer – Prostate
Cancer – Testicular
Endocannabinoids as Guardians of Metastasis
Cancer – Lymphoma
Expression and Functional Relevance of Cannabinoid Receptor 1 in Hodgkin Lymphoma
The potential relevance of the endocannabinoid 2 arachidonoylglycerol in diffuse large B cell lymphoma